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Dr.
Lidija Kovačič
Department of Molecular and Biomedical Sciences
Jozef Stefan Institute
Jamova 39
SI-1000 Ljubljana
Slovenia
tel.: +386 1 477 37 65
fax: +386 1 477 39 84
email: lidija.kovacic{afna}ijs.si
University
Education:
2009, Ph. D., Biochemistry and
Molecular Biology, Medical Faculty, University of Ljubljana (PhD
thesis summary).
2004, B. Sc., Faculty of Chemistry and Chemical Technology (FCCT), University
of Ljubljana.
Employment and Experience
2011-: postdoctoral research associate at the
Department of Molecular
and Biomedical Sciences, Jožef Stefan Institute, Ljubljana,
Slovenia.
2009-2011: postdoctoral research associate
at the
NMR Spectroscopy Research Group, Bijvoet Center for Biomolecular Research,
Utrecht University, Utrecht, The Netherlands.
2004-2009: full-time Ph.D. student at the Department of Molecular and
Biomedical Sciences, "Jožef Stefan"
Institute, Ljubljana, Slovenia.
Participation
in Current Research Projects:
Vipera ammodytes ammodytes, venom, haemostasis, anticoagulant phospholipase
A2, fibrinolitic metalloproteinase, antitrombotics basic project (J3-4100).
Project
leader: Structural explanation of the high increase in enzymatic activity of
secreted phospholipases A2 in complex with calmodulin by high resolution NMR
(Z1-4071).
Toxins in biomembranes (P1-0207).
Teaching
Positions:
2004-: Teaching assistant trainee for biochemistry at the University of
Ljubljana, Ljubljana, Slovenia.
2009-2011: Teaching
assistant trainee for biochemistry at the Utrecht University, Utrecht,
Slovenia.
Awards
and Fellowships:
"Pregel" Award of the FCCT for best PhD theses, 2010.
"Prešeren" Award of the FCCT for students, 1998.
Member of the Slovenian Biochemical Society.
Bibliography:
COBISS or PubMed
Original
Scientific Article
1. PETERS, Fabian,
MAESTRE-MARTINEZ, Mitcheell, LEONOV, Andrei, KOVAČIČ, Lidija, BECKER,
Stefan, BOELENS, Rolf, GRIESINGER, Christian. Cys-Ph-TAHA : a lanthanide
binding tag for RDC and PCS enhanced protein NMR. J. Biomol. NMR, 2011, vol.
51, no. 3, 329-337
2. NOVINEC, Marko, KOVAČIČ,
Lidija, LENARČIČ, Brigita, BAICI, Antonio. Conformational flexibility and
allosteric regulation of cathepsin K. Biochem. j. (Lond., 1984), 2010, vol.
429, no. 2, 379-389
3. KOVAČIČ, Lidija, NOVINEC,
Marko, PETAN, Toni, KRIŽAJ, Igor. Structural basis of the significant
calmodulin-induced increase in the enzymatic activity of secreted
phospholipases A2. Protein engineering, design & selection, 2010, vol. 23,
no. 6, 479-487
4. KOVAČIČ, Lidija, NOVINEC,
Marko, PETAN, Toni, BAICI, Antonio, KRIŽAJ, Igor. Calmodulin is a
non-essential activator of secretory phospholipase A2. Biochemistry
(Easton), 2009, vol. 48, no. 47, 11319-11328
5. JENKO PRAŽNIKAR, Zala,
KOVAČIČ, Lidija, ROWAN, Edward G., ROMIH, Rok, RUSMINI, Paola, POLETTI,
Angelo, KRIŽAJ, Igor, PUNGERČAR, Jože. A presynaptically toxic secreted
phospholipase A2 is internalized into motoneuron-like cells where it is
rapidly translocated into the cytosol. Biochim. biophys. acta, Mol. cell
res., 2008, vol. 1783, no. 6, 1129-1139
6. HALASSY, Beata, HABJANEC,
Lidija, BRGLES, Marija, LANG BALIJA, Maja, LEONARDI, Adrijana, KOVAČIČ,
Lidija, PRIJATELJ, Petra, TOMAŠIĆ, Jelka, KRIŽAJ, Igor. The role of
antibodies specific for toxic sPLA2s and haemorrhagins in neutralizing
potential of antisera raised against Vipera ammodytes ammodytes venom. Comp.
biochem. physiol., Toxicol. pharmacol., 2008, vol. 148, no. 2, 178-183
7. NOVINEC, Marko, KOVAČIČ,
Lidija, ŠKRLJ, Nives, TURK, Vito, LENARČIČ, Brigita. Recombinant human SMOCs
produced by in vitro refolding : calcium-binding properties and interactions
with serum proteins. Protein expr. purif., 2008, issue 1, vol. 62, 75-82
8. PREMZL, Aleš, KOVAČIČ,
Lidija, HALASSY, Beata, KRIŽAJ, Igor. Generation of
ammodytoxin-anti-cathepsin B immuno-conjugate as a model for delivery of
secretory phospholipase A2 into cancer cells. Toxicon (Oxford)., 2008, vol.
51, no. 5, 754-764
9. KOVAČIČ, Lidija, ŠRIBAR,
Jernej, KRIŽAJ, Igor. A new photoprobe for studying biological activities of
secreted phospholipases A2. Bioorg. chem., 2007, vol. 35, 295-305
10. ŠRIBAR, Jernej, KOVAČIČ,
Lidija, DRAŠKOVIČ, Petra, FAURE, Grazyna, KRIŽAJ, Igor. The first
phospholipase inhibitor from the serum of Vipera ammodytes ammodytes. FEBS
journal, 2007, vol. 274, no. 23, 6055-6064
11. ČIMBORA, Tamara, BOMBEK,
Sergeja, KOŠMRLJ, Janez, KOVAČIČ, Lidija, POLANC, Slovenko, KATALINIĆ, Ana,
OSMAK, Maja. Development of potential anti-cancer agents : diazenes and
derivatives. Drug dev. res., 2004, vol. 61, no. 2, 95-100.
Published scientific conference
contribution abstract - invited lecture
1. KOVAČIČ, Lidija. Probing
the allosteric states of the lactose repressor protein. Breakthroughs in NMR
of structural biology. The second Bio-NMR Annual User Meeting, Portorož,
Slovenia, May 8-11, 2012
2. OBERČKAL, Jernej, KOVAČIČ,
Lidija, KRIŽAJ, Igor. Synaptotagmin 1 is a novel receptor for ammodytoxin.
From molecules to life and back : book of abstract. Rijeka, Croatian Society
of Biochemistry and Molecular biology, 2012
3. KRIŽAJ, Igor, MATTIAZZI,
Mojca, ŠRIBAR, Jernej, KOVAČIČ, Lidija, PETROVIČ, Uroš. Ammodytoxin : a
window into understanding presynaptic toxicity of secreted phospholipases
A2. 9th Congress of the Slovenian Biochemical Society [also] 5th Congress of
the Slovenian Microbiological Society with International Participation
[also] 3rd CEFORM (Central European Forum for Microbiology), Maribor, 12- 15
October 2011
4. KRIŽAJ, Igor, ŠRIBAR,
Jernej, KOVAČIČ, Lidija, MATTIAZZI, Mojca, PETROVIČ, Uroš. Ammodytoxin : a
window into understanding presynaptic toxicity of secreted phospholipases
A2. V: 17th Congress of the European Section of the International Society on
Toxinology, 11-15 September 2011
Independent scientific component
part or a chapter in a monograph
1. KOVAČIČ, Lidija, BOELENS,
Rolf. Protein - DNA interactions. V: BERTINI, Ivano (ur.), MCGREEVY,
Kathleen S. (ur.), PARIGI, Giacomo (ur.). NMR of biomolecules : towards
mechanistic systems biology. Weinheim; Chichester: Wiley-VCH, 2012, 239-252
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