Peroxisomes are dynamic membrane bound organelles, capable of adapting to diverse cellular end environmental conditions. Their ability to perform various metabolic functions relies on successful import of matrix proteins. Impairment of peroxisome functions leads to many diseases (PBD – peroxisome biogenesis disorders), such as the Zellweger syndrome. Inheritance and regulation of size and abundance of peroxisomes in cell is not yet fully understood.

Pex11 was the first protein identified to have a role in peroxisome biogenesis in yeast. Using condition dependent SGA technique, we plan to identify genetic interactions of this evolutionary predecessor of nuclear receptors, and hopefully shed some light on other, more elusive roles it has in cellular processes in yeast.