Department of Biochemistry and Molecular Biology, J. Stefan Institute

List of publications in 1999

in alphabetical order of the first authors (underlined are members of our department):

Gregor Anderluh, Igor Kri"zaj, Borut "Strukelj, Franc Guben"sek, Peter Ma"cek, Jo"ze Punger"car (1999) Equinatoxins, pore-forming proteins from the sea anemone Actinia equina, belong to a multigene family. Toxicon 37, 1391-1401 (S-632)

Gregor Anderluh, Ariana Barli"c, Zdravko Podlesek, Peter Ma"cek, Jo"ze Punger"car, Franc Guben"sek, Maria Lucia Zecchini, Mauro Dalla Serra, Gianfranco Menestrina (1999) Cysteine-scanning mutagenesis of an eukaryotic pore-forming toxin from sea-anemone. Eur. J. Biochem. 263, 128-136 (S-636)

Bla"z Cigi'c, Roger H. Pain (1999) Competitive inhibition of cathepsin C by guanidinium ions and reexamination of substrate inhibition. Biochem. Biophys. Res. Comm. 258, 6-10 (S-626)

Bla"z Cigi'c, Roger H. Pain (1999) Location of the binding site for chloride ion activation of cathepsin C. Eur. J. Biochem. 264, 933-951 (S-644)

Nina Cimerman, Mojca Trstenjak Prebanda, Boris Turk, Tatjana Popovi"c, Iztok Dolenc, Vito Turk (1999) Interactions of cystatin C with papain and human cathepsins B, H and L. J. Enzyme Inhibition 14, 167-174 (S-617)

Nina Cimerman, Pika Me"sko Brguljan, Marta Kra"sovec, Stanislav "Su"skovi"c, Janko Kos (1999) Circadian characteristics of cathepsins B, H, L, and stefins A and B, potential markers for disease, in normal sera. Clin. Chim. Acta282, 211-218 (S-624)

Alenka "Copi"c, Nata"sa Vu"cemilo, Franc Guben"sek, Igor Kri"zaj (1999) Identification and purification of a novel receptor for secretory phospholipase A2 in porcine cerebral cortex. J. Biol. Chem. 274, 26315-26320 (S-638)

Gregor Gun"car, Galina Punger"ci"c, Ivica Klemen"ci"c, Vito Turk,Du"san Turk (1999) Crystal structure of MHC class II-associated p41Ii fragment bound to cathepsin L reveals the structural basis for differentiation between cathepsins L and S. EMBO J. 18, 793-803 (S-619)

Roman Jerala, Eva "Zerovnik (1999) Accessing the global minimum conformation of stefin A dimer by annealing under partially denaturingconditions. J. Mol. Biol. 291, 1079-1089 (S-639)

N. Katunuma, E. Murata, H. Kakegawa, A. Matsui, H. Tsuzuki, H. Tsuge, D. Turk, V. Turk , M. Fukushima, Y. Tada, T. Asao (1999) Structure based development of novel specific inhibitors for cathepsin L and cathepsin S in vitro and in vivo. FEBS Lett. 458, 6-10 (S-653B)

Nata"sa Kopitar-Jerala, Roman Jerala, Boris Turk, Franc Guben"sek, Vito Turk (1999) Mutational analysis of two stefin A epitopes. Biol.Chem. 380, 723-726 (S-631)

Nata"sa Kopitar-Jerala, Vito Turk (1999) A procathepsin D specific monoclonal antibody that recognizes procathepsin D but not cathepsin D. Immunol. Lett. 70, 211-212 (S-653)

Du"san Koridi"s, Franc Guben"sek (1999) Molecular evolution ofBov-B LINEs in vertebrates. Gene 238, 171-178 (S-641)

Du"san Kordi"s, Franc Guben"sek (1999) Horizontal transfer of non-LTR retrotransposons in vertebrates. Genetica 107, 121-128 (S-672)

Janko Kos (1999) More on cystatin C. Clin. Chemistry 45, 719 (letter to the editor) (S-627)

Igor Kregar, Borut "Strukelj (1999) Proteinase inhibitors offer the possibility of producing disease resistant transgenic potatoes. Food Technol. Biotechnol. 37 (1), 39-44 (S-620)

Brigita Lenar"ci"c, Vito Turk (1999) Thyroglobulin type-1 domains in equistatin inhibit both papain-like cysteine proteinases and cathepsin D. J. Biol. Chem. 274 (2), 563-566 (S-615)

Adrijana Leonardi, Federico Aragon-Ortiz, Franc Guben"sek, Igor Kri"zaj (1999) Partial primary structure of a fibrogenase from the venom of the snake Lachesis stenophrys. J. Chromatogr. A 852, 237-243(S-637)

Tatjana Popovi"c, Nina Cimerman, Iztok Dolenc, Anka Ritonja, Jo"ze Brzin (1999) Cathepsin L is capable of truncating cystatin Cof 11 N-terminal amino acids. FEBS Lett. 455, 92-96 (S-635)

Jo"ze Punger"car, Igor Kri"zaj, Ning-Sheng Liang, Franc Guben"sek (1999) An aromatic, but not a basic, residue is involved in the toxicity of group-II phospholipase A2 neurotoxins. Biochem. J. 341, 139-145 (S-630)

Barbka Repi"c Lampret, Jurka Kidri"c, Bogdan Kralj, Ljubinka Vitale, Miroslav Pokorny, Metka Renko (1999) Lapstatin, a new aminopeptidase inhibitor produced by Streptomyces rimosus, inhibits autogenous aminopeptidases. Arch. Microbiol. 171, 397-404 (S-633)

Jerica Rozman, Jure Stojan, Robert Kuhelj, Vito Turk, Boris Turk (1999) Autocatalytic processing of recombinant human procathepsin B is a bimolecular process. FEBS Lett. 459, 358-362 (S-643)

Veronika Stoka, Brigita Lenar"ci"c, Juan Jose Cazzulo, VitoTurk (1999) Cathepsin S and cruzipain are inhibited by equistatin from Actinia equina. Biol. Chem. 380, 589-592 (S-625)

Primo"z Strojan, Marjan Budihna, Lojze "Smid, Branka Svetic, Ivan Vrhovec, Janko Kos, Janez "Skrk (1999) Cathepsin H in squamous cell carcinoma of the head and neck. Radiol. Oncol. 33, 143-151 (S-628)

Tadej Strojnik, Janko Kos, Boris "Zidanik, Rastko Golouh, Tamara Lah (1999) Cathepsin B immunohistochemical staining in tumor and endothelial cells is a new prognostic factor for survival in patients with brain tumors. Clin. Cancer Res. 5, 559-567 (S-621)

Hideaki Tsuge, Tomohiro Nishimura, Yukio Tada, Tetsuji Asao, Dusan Turk, VitoTurk , Nobuhiko Katunuma (1999) Inhibition mechanism of cathepsin L-specific inhibitors based on the crystal structure of papain-CLIK148 complex. Biochem. Biophys. Res. Comm. 266, 411-416 (S-653A)

Boris Turk, Iztok Dolenc, Brigita Lenar"ci"c, Igor Kri"zaj, VitoTurk , Joseph G. Bieth, Ingemar Björk (1999) Acidic pH as a physiological regulator of human cathepsin L activity. Eur. J. Biochem. 259, 926-932(S-618)

Boris Turk (1999) Caspases: the central proteolytic machinery of apoptosis. Futura 14 (1)12-20 (S-622)

Boris Turk, Raymond Awad, Elena V. Usova, Ingemar Björk,Staffan Eriksson (1999) A pre-steady-state kinetic analysis of substrate binding to human recombinant deoxycytidine kinase: A model for nucleoside kinase action. Biochemistry 38, 8555-8561 (S-629)

Du"san Turk, Gregor Gun"car, Vito Turk (1999) The p41 fragment story. IUBMB Life 48, 7-12 (S-642)

Bernd Werle, Alexander Staib, Britta Jülke, Werner Ebert, PavelZladoidsky, Andreja Sekirnik, Janko Kos, Eberhard Spiess (1999) Fluorometric microassays for the determination of cathepsin L and cathepsin S activities in tissue extracts. Biol. Chem. 380, 1109-1116 (S-640)

B. Werle, W. Loetterle, U. Schanzenbaecher, T.T. Lah, E. Kalman, K.Kayser, H. Buelzebruck, J. Schirren, M. Krasovec, J. Kos, E. Spiess (1999) Immunochemical analysis of cathepsin B in lung tumours: an independentprognostic factor for squamous cell carcinoma patients. Brit. J. Cancer 81, 510-519 (S-645)

P. Zrim"sek, J. Kos, L. Pinter, M. Drobni"c-Ko"sorok (1999) Detection by ELISA of the humoral immune response in rabbits naturally infected with Trichophyton mentagrophytes. Veterinary Microbiol. 70, 77-86 (S-646)

Eva "Zerovnik, Vojko Janji'c, Andrej Francky, Bojana Mozeti"c-Francky (1999) Equilibrium and transient intermediates in folding of human macrophage migration inhibitory factor. Eur. J. Biochem. 260, 609-618 (S-623)

Eva "Zerovnik, Richard Virden, Roman Jerala, Louise Kroon-"Zitko, Vito Turk, Jonathan P. Waltho (1999) Differences in the effects of TFE on the folding pathways of human stefins A and B. Proteins 36, 205-216(S-634)

List of publications in 2000

in alphabetical order of the first authors (underlined are members of our department):

Veronique Arocas, Boris Turk, Susan C. Bock, Steven T. Olson, Ingemar Björk (2000) The region of antithrombin interacting with full-length heparin chains outside the high-affinity pentasaccharide sequence extends to Lys136 but not to Lys139. Biochemistry 39, 8512-8518 (S-670)

Mojca Bo"zi"c, Mojca Stegnar, Isabella Fermo, Anka Ritonja, Polona Peternel, Janez Stare, Armando D'Angelo (2000) Mild hyperhomocysteinemia and fibrinolytic factors in patients with history of venous thromboembolism. Thrombosis Res. 100, 271-278 (S-683)

Jo"ze Brzin, Boris Rogelj, Tatjana Popovi"c, Borut "Strukelj, Anka Ritonja (2000) Clitocypin, a new type of cysteine proteinase inhibitor from fruit bodies of mushroom Clitocybe nebularis. J. Biol. Chem. 275,20104-20109 (S-669)

Bla"z Cigi'c, Soren W. Dahl, Roger H. Pain (2000) The residual pro-part of  cathepsin C fulfills the criteria required for an intramolecular chaperone in folding and stabilizing the human proenzyme. Biochemistry 39, 12382-12390 (S-675)

Nina Cimerman, Pika Me"sko Brguljan, Marta Kra"sovec, Stanislav "Su"skovi"c, Janko Kos (2000) Twenty-four hour variations of cystatin C and total cysteine proteinase inhibitory activity in sera from healthy subjects. Clinica Chim. Acta 291, 89-95 (S-649)

Nina Cimerman, Pika Me"sko Brguljan, Marta Kra"sovec, Stanislav "Su"skovi"c, Janko Kos (2000) Serum cystatin C, a potent inhibitor of cysteine proteinases, is elevated in asthmatic patients. Clinica Chim. Acta 300, 83-95 (S-673)

Nina Cimerman, Pika Me"sko Brguljan, Marta Kra"sovec, Stanislav "Su"skovi"c, Janko Kos (2000) Circadian variations of serum cysteine proteinases and cystatins and their assessment in asthma. Acta Biol. Sloven. 43, 23-26 (S-689)

Alenka "Copi"c, Franc Guben"sek, Igor Kri"zaj (2000) Novel receptors for secretory phospholipases A2 discovered in porcine cerebral cortex. Acta Biol. Slov.43 (1-2), 53-56 (S-685)

Marko Dolinar, Andreja Mehle, Bojana Mozeti"c Francky, Ana Schweiger, Vito Turk (2000) Endoproteolytic pattern observed during refolding of a human exopeptidase proenzyme, procathepsin H, produced in Escherichia coli. Food Technol. Biotechnol. 38, 5-9 (S-656)

Robert Frange"z, Igor Kri"zaj, Franc Guben"sek, Du"san "Suput (2000) Effects of ammodytin L on miniature and endplate potentials in neuromuscular junction of frog m. cutaneus pectoris. Pflügers Arch. - Eur. J. Physiol. 440 (Suppl.)R101-R102 (S-686)

Katja Gale"sa, Borut "Strukelj, Sa"so Bavec, Vito Turk, Brigita Lenar"ci"c (2000) Cloning and expression of functional equistatin. Biol. Chem. 381,85-88 (S-651)

K. Gruden, B. "Strukelj, M. Ravnikar, B. Herzog-Velikonja (2000) A putative viral resistance-connected protein isolated from potato cultivar Sante resistant to PVY(NTN) infection. Phyton 40, 191-200 (S-668)

Kristina Gruden, Maarten A. Jongsma, Blagajana Herzog-Velikonja, Borut "Strukelj (2000) Adaptation of Colorado Potato Beetle to plant defense mechanism. Acta Biol. Slov. 43 (1-2), 89-92 (S-687)

Gregor Gun"car, Ivica Klemen"ci"c, Boris Turk, Vito Turk, Adriana Karaoglanovic-Carmona, Luiz Juliano, Du"san Turk (2000) Crystal structure of cathepsin X: a flip-flop of the ring of His23 allows carboxy-monopeptidase and carboxy-dipeptidase activity of the protease. Structure 8, 305-313(S-658)

Gabriela Ivanovski, Alenka "Copi"c, Igor Kri"zaj, Franc Guben"sek, Jo"ze Punger"car (2000) The amino acid region 115-119 of ammodytoxins plays an important role in neurotoxicity. Biochem. Biophys. Res. Comm. 276, 1229-1234 (S-676)

Roman Jerala, Eva "Zerovnik (2000) Dimerization of human stefin A under partially denaturing conditions. Acta Biol. Sloven. 43, 83-87 (S-690)

Ivica Klemen"ci"c, Adriana K. Carmona, Maria Helena S. Cezari, Maria A. Juliano, Luiz Juliano, Gregor Gun"car, Du"san Turk, Igor Kri"zaj, Vito Turk, Boris Turk (2000) Biochemical characterization of human cathepsin X revealed that the enzyme is an exopeptidase, acting as carboxymonopeptidase or carboxydipeptidase. Eur. J. Biochem. 267, 5404-5412 (S-674)

Nata"sa Kopitar-Jerala, Marco Bestagno, Xiaohui Fan, Djurdja Novak-Despot, Oscar Burrone, Janko Kos, Janez "Skrk, Franc Guben"sek (2000) Molecular cloning and chimerisation of CDI 315B monoclonal antibody. Pflügers Arch. - Eur. J. Physiol. 439 (Suppl.) R796-R80 (S-650)

Nata"sa Kopitar-Jerala, Franc Guben"sek, Vito Turk (2000) Recombinant anti-stefin A Fab fragment: Sequence analysis of the variable region and expression in Escherichia coli. Biol. Chem. 381, 1245-1249 (S-681)

Du"san Kordi"s, Franc Guben"sek (2000) Adaptive evolution of animal toxin multigene families. Gene 261, 43-52 (S-688)

Janko Kos, Marta Kra"sovec, Nina Cimerman, Hans Jorgen Nielsen, Ib Jarle Christensen, Nils Brünner (2000) Cysteine proteinase inhibitors stefin A, stefin B, and cystatin C in sera from patients with colorectal cancer: Relation to prognosis. Clin. Cancer Res. 6, 505-511 (S-652)

J. Kos, B. Werle, T. Lah, N. Brunner (2000) Cysteine proteinases and their inhibitors in extracellular fluids: Markers for diagnosis and prognosis in cancer. Int. J. Biol. Markers 15, 84-89 (S-661)

I. Kri"zaj, Franc Guben"sek (2000) Neuronal receptors for phospholipases A2 and beta-neurotoxicity. Biochimie 82, 807-814 (S-678)

T.T. Lah, T. Strojnik, N. Levi"car, A. Bervar, I. Zajc, G. Pilkington, J.Kos (2000) Clinical and experimental studies of cysteine cathepsins and their inhibitors in human brain tumors. Int. J. Biol. Markers 15, 90-92 (S-662)

Tamara T. Lah, Miha "Cer"cek, Andrej Blejec, Janko Kos, Ella Gorodetsky, Robert Somers, Ierachmiel Daskal (2000) Cathepsin B, a prognostic indicator in lymph-node negative breast carcinoma patients: Comparison with cathepsin D, cathepsin L, and other clinical indicators. Clin. Cancer Res. 6, 578-584 (S-660)

Brigita Lenar"ci"c, Gomathi Krishnan, Renata Borukhovich, Brian Ruck, Vito Turk, Edward Moczydlowski (2000) Saxiphilin, a saxitoxin-binding protein with two thyroglobulin type 1 domains, is an inhibitor of papain-like cysteine proteinases. J. Biol. Chem. 275, 15572-15577 (S-665)

Brigita Lenar"ci"c, Katja Gale"sa, Edvard Moczydlowski, Vito Turk (2000) Thyropins, a group of new structurally related inhibitors. Acta Biol. Slov. 43 (1-2), 7-10 (S-684)

Petra Prijatelj, Alenka "Copi"c, Igor Kri"zaj, Franc Guben"sek, Jo"ze Punger"car (2000) Charge reversal of ammodytoxin A, a phospholipase A2-toxin, does not abolish its neurotoxicity. Biochem. J. 352, 251-266 (S-677)

Jo"ze Punger"car, Gabriela Ivanovski (2000) Identification and molecular cloning of cathepsin P, a novel human putative cysteine protease of the papain family. Pflügers Arch. - Eur. J. Physiol. 439 (Suppl.)R116-R118 (S-647)

Jo"ze Punger"car, Alenka Viyjak, Gabriela Ivanovski, Igor Kri"zaj (2000) Tissue expression and immunolocalization of a novel human cathepsin P. Pflügers Arch. - Eur. J. Physiol. 439 (Suppl.)R119-R121 (S-648)

Boris Rogelj, Borut "Strukelj, Dirk Bosch, Maarten A. Jongsma (2000) Expression, purification and characterization of Equistatin in Pichia pastoris. Prot. Expr. Purif. 19, 329-334 (S-671)

Cornelis F.M. Sier, Giovanni Casetta, Jan H. Verheijen, Alessandro Tizzani, Vittorio Agape, Janko Kos, Francesco Blasi, Roeland Hanemaaijer (2000) Clin. Cancer Res. 6, 2333-2340 (S-667)

Ana Schweiger, A. Steib, Bernd Werle, Marta Kra"sovec, TamaraT. Lah, W. Ebert, Vito Turk, Janko Kos (2000) Cysteine proteinase cathepsin H in tumours and sera of lung cancer patients: relation to prognosisand cigarette smoking. Brit. J. Cancer 82, 782-788 (S-655)

Rosemary A. Staniforth, Jonathan L.E. Dean, Qi Zhong, Eva Zerovnik , Anthony R. Clarke, Jonathan P. Waltho (2000) The major transition state in folding need not involve the immobilization of side chains. Proc. Natnl. Acad. Sci USA 97, 5790-5795 (S-666)

Veronika Stoka, Boris Turk, James H. McKerrow, Ingemar Björk, Juan Jose Cazzulo, Vito Turk (2000) The high stability of cruzipain against pH-induced inactivation is not dependent on its C-terminal domain. FEBS Lett. 469, 29-32 (S-657)

Primo"z Strojan, Marjan Budihna, Lojze "Smid, Branka Svetic, Ivan Vrhovec, Janko Kos, Janez "Skrk (2000) Prognostic significance of cysteine proteinases cathepsins B and L and their endogenous inhibitors stefins A and B in patients with squamous cell carcinoma of the head and neck. Clin. Cancer Res. 6,1052-1062 (S-659)

Tadej Strojnik, Irena Zajc, Ale"s Bervar, Boris "Zidanik, Rastko Golouh, Janko Kos, Vinko Dolenc, Tamara Lah (2000) Cathepsin B and its inhibitor stefin A in brain tumors. Pflügers Arch. - Eur. J. Physiol. 439 (Suppl.)R122-R123 (S-654)

Borut "Strukelj, Brigita Lenar"ci"c, Kristina Gruden, Jo"ze Punger"car, Boris Rogelj, Vito Turk, Dirk Bosch, Maarten Jongsma (2000) Equistatin, a protease inhibitor from the sea anemone Actinia equina, is composed of three structural and functional domains. Biochem. Biophys. Res. Comm.269, 732-736 (S-664)

Boris Turk, Du"san Turk, Vito Turk (2000) Lysosomal cysteine proteases: more than scavengers. Biochim. Biophys. Acta 1477, 98-111 (S-663)

Bernd Werle, Clemens Kraft, Tamara T. Lah, Janko Kos, Ulrike Schanzenbächer, Klaus Kayser, Werner Ebert, Eberhard Spiess (2000) Cathepsin B in infiltrated lymph nodes is of prognostic significance for patients with nonsmall cell lung carcinoma. Cancer 89, 2282-2291 (S-682)

Last updated: April 20, 2001 (last reprint S-690).

Confused by Slovenian characters ("c,"s,"z)? Here is the explanation of Slovenian alphabet.

Back to the Department's homepage.